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KMID : 0881720190340060591
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Journal of Food Hygiene and Safety
2019 Volume.34 No. 6 p.591 ~ p.594
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Synergistic Inhibition of Escherichia coli by a Combination of Bacteriophage and Organic Acid
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Kim Seon-Gyu
Moon Gi-Seong
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Abstract
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Some strains of Escherichia coli are categorized as pathogenic bacteria and alternative antimicrobials including bacteriophages for controlling these bacteria have been studied. In this study we screened antimicrobial candidates that present synergistic inhibition of the growth of E. coli DH5α as a model when co-treated with the bacteriophage ECP27 to target the bacteria. As candidates, CaCl 2 , lactic acid, and citric acid were tested. CaCl 2 showed a synergistic inhibition against the strain by dose-dependent manner at 6 h of incubation but the viable cell count was recovered at 12 h. However, lactic acid and citric acid at 30 mM concentration showed synergistic inhibitions at 6 h of incubation and cleared the viable cells of E. coli DH5α at 12 h when co-treated with the bacteriophage even though lactic acid or citric acid alone was effective. Therefore, co-treatment using the bacteriophage and organic acids such as lactic acid and citric acid can be a solution for synergistic inhibition of the growth of E. coli.
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KEYWORD
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Synergistic inhibition, Escherichia coli, Bacteriophage, Lactic acid, Citric acid
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